1. Do not build in cold areas, compared to hyperthermia, there is no block to prevent hypothermia. (this includes in the ground/mountain)
2. Build tall, the large creatures are able to walk over structures up to 6 blocks high.
3. Focus Research (Engrams) on tools. While the Copper Pickaxe is pretty good as you progress you are going to need larger amounts of rock (stone) and ores. So you are going to want at least have the Iron Pickaxe as it takes a single swing to remove rock and three swings for ores.